Given the improvements at Chelsea and Arsenal, it will still be a significant achievement for United to secure a top four finish and in the Champions League, a decent run in the knockout stages would also be a sign of progress.
Steven Bergwijn scored twice in stoppage time as Tottenham Hotspur stunned Leicester City and pulled off a remarkable 3-2 victory in the Premier League on Wednesday.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Bruno Fernandes struck from the penalty spot in the ninth minute of stoppage time to give Manchester United victory at Brighton & Hove Albion in the Premier League on Saturday after an incredible finale.
Manchester United took a big step towards the Europa League quarter-finals by thrashing Austrian side LASK Linz 5-0 on Thursday in their last 16 first-leg tie at an empty Linzer Stadium due to the coronavirus pandemic.
United looked dead and buried as they struggled to get back into the contest after the break but 19-year-old Brandon Williams's first senior goal 18 minutes from time sparked them into life. However, substitute McBurnie denied the visitors in stoppage time to add a further twist to the breathless encounter, squeezing a strike past De Gea, with the goal awarded after a lengthy VAR review.
On a good night for English clubs in the Europa League, Manchester United hammered AZ Alkmaar 4-0, while Wolverhampton Wanderers also thrashed Besiktas 4-0 in Group K, and Arsenal came from two goals down to draw 2-2 away to Standard Liege and finish first in their pool. The upset of the night came in Group J as Crivelli scored a 90th-minute winner against Borussia Moenchengladbach to send Basaksehir through and knock the Germans out, with AS Roma grabbing the runner-up spot thanks to a 2-2 home draw with Wolfsberger as the Europa League group stage concluded on Thursday.
Manchester United were forced to dig deep to reach the Europa League semi-finals as Portuguese midfielder Bruno Fernandes converted a 95th-minute penalty to secure a 1-0 win over a stubborn FC Copenhagen side after extra time on Monday.
United looked more solid after the introduction of midfielder Nemanja Matic at the break and got a foothold in the tie through a 70th-minute goal from Marcus Rashford.
IMAGES from the Europa League semifinal played between Manchester United and Sevilla in Cologne on Sunday.
Manchester United's current malaise was laid bare as they struggled past third-tier Rochdale 5-3 on penalties after a 1-1 draw in the League Cup third round.
Updates from around the different clubs in the English Premier League
Ousmane Dembele struck early and Lionel Messi converted a late penalty as Barcelona won 2-0 at Juventus in the Champions League on Wednesday after Alvaro Morata had three goals disallowed for offside for the Serie A side.
Liam Delap, the son of former Stoke City defender Rory, scored the opener for Pep Guardiola's side in the 2-1 win at the Etihad Stadium
Here are six who could make the biggest impact in this season's English Premier League.
Manchester United, Sevilla and Celtic led a parade of clubs with continental pedigree to book the first places in this season's Europa League knockout stage.
News of all that tranpired on and off the football field.
Whatever happens in the title battle between Manchester City and Liverpool, which will go down to the final day of the season
Manchester United's Bruno Fernandes fired home a late penalty to rescue a point for the visitors in a lively 1-1 draw at Tottenham Hotspur in the Premier League on Friday.
Yuvraj Singh said he has been following Manchester United for more than 20 years
United down Newcastle after Saints stun Chelsea on a dramatic night in the English Premier League.
Images from Saturday's action in the English Premier League.
A round-up of Saturday's action in the Premier League.
Martial scored his 23rd goal for United in all competitions this season against LASK Linz in Wednesday's Europa League last-16 victory.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Barcelona crashed out of the Champions League following a 3-0 defeat at Bayern Munich on Wednesday, failing to make it past the group stage of the competition for the first time since the 2000-01 season.
France earned a rollercoaster 4-2 home win over Croatia in an entertaining top-tier Nations League Group 3 match, while England were held to a 0-0 draw by Denmark in an uninspiring game.
IMAGES from Saturday's English Premier League matches.
Diogo Jota and Joao Felix both scored their first international goals in the second half before Bruno Petkovic pulled one back and Andre Silva then added a fourth.
Kazakhstan's Astana fought back to beat a youthful Manchester United side 2-1 at home, Arsenal's woes continued as Frankfurt's Daichi Kamada scored twice to secure a 2-1 win.
Photos from the Premier League matches played on Sunday
News of all that's transpired on and off the football field
McTominay injury takes gloss of vibrant United display
Leicester City's Kelechi Iheanacho scored two poacher's goals as they beat Manchester United 3-1 in their FA Cup quarter-final on Sunday to set up a last-four clash against Southampton.
Liverpool surrendered a two-goal lead as they were held to a 2-2 draw by third-tier Shrewsbury Town in the FA Cup fourth round on Sunday after second-half substitute Jason Cummins struck twice to inject some much-needed late magic into the competition. Earlier, Harry Maguire's thunderbolt for Manchester United started a goal rush at Tranmere where the Reds scored five times before halftime. Diogo Dalot, Jesse Lingard, Phil Jones, Anthony Martial and Mason Greenwood also scored.
Juventus progressed to the Champions League last 16 after a Cristiano Ronaldo goal and a late header from substitute Alvaro Morata gave them a comeback 2-1 home win over Hungarians Ferencvaros on Tuesday.
Rodriguez whipped Everton in front from the edge of the box, and Michael Keane and Calvert-Lewin ensured it was two wins from two in the Premier League so far this season.
Images from the English Premier League matches played on Saturday.
Images from the English Premier League matches played on Wednesday.
IMAGES from Premier League matches played on Saturday.